The influence of early-life microbial exposures on long-term respiratory health

Title: The influence of early-life microbial exposures on long-term respiratory health
Creator: Taylor, Steven L.; Simpson, Jodie L.; Rogers, Geraint B.
Relation: Paediatric Respiratory Reviews Vol. 40, Issue December 2021, p. 15-23
Publisher Link: http://dx.doi.org/10.1016/j.prrv.2021.05.003
Publisher: Elsevier
Resource Type: journal article
Date: 2021
Description: Host-microbiome interactions exert a profound influence on human physiology and health outcomes. In particular, certain characteristics of commensal microbiota during a critical period in early life are essential for the establishment of immune tone and metabolic control. An increasing body of evidence suggests that early life exposures that disrupt these interactions can substantially influence life-long risks for respiratory disease. Here, we explore how such early life exposures, including antibiotic exposure, maternal diet, preterm birth, mode of delivery, breastfeeding, and environmental variables shape the infant microbiome, and the mechanisms by such changes can in turn impact respiratory health.
Subject: microbiota; infant; asthma; pulmonary disease; chronic obstructive; anti-bacterial agents; SDG 3; Sustainable Development Goals
Identifier: http://hdl.handle.net/1959.13/1492695
Identifier: uon:53400
Identifier: ISSN:1526-0542
Language: eng
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